Volatile organic compounds generated by cultures of bacteria and viruses associated with respiratory infections.
Identifieur interne : 000C98 ( Main/Exploration ); précédent : 000C97; suivant : 000C99Volatile organic compounds generated by cultures of bacteria and viruses associated with respiratory infections.
Auteurs : Amir Abd El Qader [Israël] ; David Lieberman [Israël] ; Yonat Shemer Avni [Israël] ; Natali Svobodin [Israël] ; Tsilia Lazarovitch [Israël] ; Orli Sagi [Israël] ; Yehuda Zeiri [Israël]Source :
- Biomedical chromatography : BMC [ 1099-0801 ] ; 2015.
Descripteurs français
- KwdFr :
- Bactéries (métabolisme), Chromatographie gazeuse-spectrométrie de masse (), Composés organiques volatils (analyse), Composés organiques volatils (métabolisme), Cyclohexanes (analyse), Cyclohexanes (métabolisme), Heptanes (analyse), Heptanes (métabolisme), Humains, Infections bactériennes (microbiologie), Infections de l'appareil respiratoire (microbiologie), Infections de l'appareil respiratoire (virologie), Maladies virales (virologie), Marqueurs biologiques (analyse), Marqueurs biologiques (métabolisme), Virus (métabolisme).
- MESH :
- analyse : Composés organiques volatils, Cyclohexanes, Heptanes, Marqueurs biologiques.
- microbiologie : Infections bactériennes, Infections de l'appareil respiratoire.
- métabolisme : Bactéries, Composés organiques volatils, Cyclohexanes, Heptanes, Marqueurs biologiques, Virus.
- virologie : Infections de l'appareil respiratoire, Maladies virales.
- Chromatographie gazeuse-spectrométrie de masse, Humains.
English descriptors
- KwdEn :
- Bacteria (metabolism), Bacterial Infections (microbiology), Biomarkers (analysis), Biomarkers (metabolism), Cyclohexanes (analysis), Cyclohexanes (metabolism), Gas Chromatography-Mass Spectrometry (methods), Heptanes (analysis), Heptanes (metabolism), Humans, Respiratory Tract Infections (microbiology), Respiratory Tract Infections (virology), Virus Diseases (virology), Viruses (metabolism), Volatile Organic Compounds (analysis), Volatile Organic Compounds (metabolism).
- MESH :
- chemical , analysis : Biomarkers, Cyclohexanes, Heptanes, Volatile Organic Compounds.
- metabolism : Bacteria, Biomarkers, Cyclohexanes, Heptanes, Viruses, Volatile Organic Compounds.
- methods : Gas Chromatography-Mass Spectrometry.
- microbiology : Bacterial Infections, Respiratory Tract Infections.
- virology : Respiratory Tract Infections, Virus Diseases.
- Humans.
Abstract
Respiratory infections (RI) can be viral or bacterial in origin. In either case, the invasion of the pathogen results in production and release of various volatile organic compounds (VOCs). The present study examines the VOCs released from cultures of five viruses (influenza A, influenza B, adenovirus, respiratory syncitial virus and parainfluenza 1 virus), three bacteria (Moraxella catarrhalis, Haemophilus influenzae and Legionella pneumophila) and Mycoplasma pneumoniae isolated colonies. Our results demonstrate the involvement of inflammation-induced VOCs. Two significant VOCs were identified as associated with infectious bacterial activity, heptane and methylcyclohexane. These two VOCs have been linked in previous studies to oxidative stress effects. In order to distinguish between bacterial and viral positive cultures, we performed principal component analysis including peak identity (retention time) and VOC concentration (i.e. area under the peak) revealing 1-hexanol and 1-heptadecene to be good predictors.
DOI: 10.1002/bmc.3494
PubMed: 26033043
Affiliations:
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Beer-Sheva</wicri:regionArea><wicri:noRegion>Beer-Sheva</wicri:noRegion></affiliation></author><author><name sortKey="Lazarovitch, Tsilia" sort="Lazarovitch, Tsilia" uniqKey="Lazarovitch T" first="Tsilia" last="Lazarovitch">Tsilia Lazarovitch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology, Assaf Harofeh Medical Center, Zerifin, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Clinical Microbiology, Assaf Harofeh Medical Center, Zerifin</wicri:regionArea><wicri:noRegion>Zerifin</wicri:noRegion></affiliation></author><author><name sortKey="Sagi, Orli" sort="Sagi, Orli" uniqKey="Sagi O" first="Orli" last="Sagi">Orli Sagi</name><affiliation wicri:level="1"><nlm:affiliation>Parasitology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Parasitology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva</wicri:regionArea><wicri:noRegion>Beer-Sheva</wicri:noRegion></affiliation></author><author><name sortKey="Zeiri, Yehuda" sort="Zeiri, Yehuda" uniqKey="Zeiri Y" first="Yehuda" last="Zeiri">Yehuda Zeiri</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Biomedical Engineering, Ben-Gurion University of the Negev, Beer-Sheva</wicri:regionArea><wicri:noRegion>Beer-Sheva</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomedical chromatography : BMC</title><idno type="eISSN">1099-0801</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bacteria (metabolism)</term><term>Bacterial Infections (microbiology)</term><term>Biomarkers (analysis)</term><term>Biomarkers (metabolism)</term><term>Cyclohexanes (analysis)</term><term>Cyclohexanes (metabolism)</term><term>Gas Chromatography-Mass Spectrometry (methods)</term><term>Heptanes (analysis)</term><term>Heptanes (metabolism)</term><term>Humans</term><term>Respiratory Tract Infections (microbiology)</term><term>Respiratory Tract Infections (virology)</term><term>Virus Diseases (virology)</term><term>Viruses (metabolism)</term><term>Volatile Organic Compounds (analysis)</term><term>Volatile Organic Compounds (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Bactéries (métabolisme)</term><term>Chromatographie gazeuse-spectrométrie de masse ()</term><term>Composés organiques volatils (analyse)</term><term>Composés organiques volatils (métabolisme)</term><term>Cyclohexanes (analyse)</term><term>Cyclohexanes (métabolisme)</term><term>Heptanes (analyse)</term><term>Heptanes (métabolisme)</term><term>Humains</term><term>Infections bactériennes (microbiologie)</term><term>Infections de l'appareil respiratoire (microbiologie)</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Maladies virales (virologie)</term><term>Marqueurs biologiques (analyse)</term><term>Marqueurs biologiques (métabolisme)</term><term>Virus (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term><term>Cyclohexanes</term><term>Heptanes</term><term>Volatile Organic Compounds</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Composés organiques volatils</term><term>Cyclohexanes</term><term>Heptanes</term><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bacteria</term><term>Biomarkers</term><term>Cyclohexanes</term><term>Heptanes</term><term>Viruses</term><term>Volatile Organic Compounds</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gas Chromatography-Mass Spectrometry</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections bactériennes</term><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bacterial Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Bactéries</term><term>Composés organiques volatils</term><term>Cyclohexanes</term><term>Heptanes</term><term>Marqueurs biologiques</term><term>Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Chromatographie gazeuse-spectrométrie de masse</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Respiratory infections (RI) can be viral or bacterial in origin. In either case, the invasion of the pathogen results in production and release of various volatile organic compounds (VOCs). The present study examines the VOCs released from cultures of five viruses (influenza A, influenza B, adenovirus, respiratory syncitial virus and parainfluenza 1 virus), three bacteria (Moraxella catarrhalis, Haemophilus influenzae and Legionella pneumophila) and Mycoplasma pneumoniae isolated colonies. Our results demonstrate the involvement of inflammation-induced VOCs. Two significant VOCs were identified as associated with infectious bacterial activity, heptane and methylcyclohexane. These two VOCs have been linked in previous studies to oxidative stress effects. In order to distinguish between bacterial and viral positive cultures, we performed principal component analysis including peak identity (retention time) and VOC concentration (i.e. area under the peak) revealing 1-hexanol and 1-heptadecene to be good predictors.</div></front></TEI><affiliations><list><country><li>Israël</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Abd El Qader, Amir" sort="Abd El Qader, Amir" uniqKey="Abd El Qader A" first="Amir" last="Abd El Qader">Amir Abd El Qader</name></noRegion><name sortKey="Lazarovitch, Tsilia" sort="Lazarovitch, Tsilia" uniqKey="Lazarovitch T" first="Tsilia" last="Lazarovitch">Tsilia Lazarovitch</name><name sortKey="Lieberman, David" sort="Lieberman, David" uniqKey="Lieberman D" first="David" last="Lieberman">David Lieberman</name><name sortKey="Sagi, Orli" sort="Sagi, Orli" uniqKey="Sagi O" first="Orli" last="Sagi">Orli Sagi</name><name sortKey="Shemer Avni, Yonat" sort="Shemer Avni, Yonat" uniqKey="Shemer Avni Y" first="Yonat" last="Shemer Avni">Yonat Shemer Avni</name><name sortKey="Svobodin, Natali" sort="Svobodin, Natali" uniqKey="Svobodin N" first="Natali" last="Svobodin">Natali Svobodin</name><name sortKey="Zeiri, Yehuda" sort="Zeiri, Yehuda" uniqKey="Zeiri Y" first="Yehuda" last="Zeiri">Yehuda Zeiri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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